Platelet Indices as a Predictive Marker for Solid Tumor Malignancy and its Association with C-reactive Protein

  • Divya Mahajan Himalayan Institute of Medical Sciences, Swami Rama Himalayan University
  • Harish Chandra
  • Smita Chandra
  • Sunil Saini

Abstract

Background: The present study was undertaken to ascertain the role of platelet indices including MPV, PDW as
a predictive marker in solid tumour malignancy and investigate its association with CRP. It was also intended to
study the correlation of platelet indices with the stage of tumour.
Material and Methods: The study included newly diagnosed cases of solid tumour malignancy on histology and/
or cytology during a period of one year. The platelet indices and CRPwere collected both pre and post treatment of
these solid tumours and values were analysed statistically.
Results: The study included 98 newly diagnosed cases of solid tumour malignancy. MPV levels of controls
(10.46+6.83 fl) was found to be higher than that of cases (10.13+1.76 fl) but this difference was not statistically
significant (p=0.640). The CRP levels of cases (12177.82+2785.60 ng/ml) were found to be significantly higher
(p<0.001) than that of controls (1170.86+796.08 ng/ml). A decline of 1.55+1.11 fl (15.29%) in MPV levels was
found pre and post treatment and this decline was found to be statistically significant (p<0.001). CRP levels
declined by 4600.18+3765.10 ng/ml (37.78%) post treatment and this decline was found to be statistically
significant (p<0.001).
Conclusion: MPV levels of cases was found to be lower than that of controls but this difference was not found to
be statistically significant which reflects that MPV cannot be used as a predictive marker in diagnosing solid
tumour malignancies. CRP values were significantly higher than control group confirming that CRP may be used
as a predictive marker in suspected cases of solid tumour malignancy. Significant reduction of MPV & CRP after
treatment, clearly indicates that inflammation plays an important role in pathogenesis of cancer. It was also
observed that MPV does not co-relate with the stage of tumour. MPV may be evaluated together with other
inflammatory markers like C-Reactive protein and haematological parameters like platelet count, haemoglobin
and red cell distribution width as predictive marker in suspected cases of solid tumour malignancies.
Key words: Platelet indices, CRP, solid tumors, mean platelet volume

Published
Apr 25, 2019
How to Cite
MAHAJAN, Divya et al. Platelet Indices as a Predictive Marker for Solid Tumor Malignancy and its Association with C-reactive Protein. SRHU MEDICAL JOURNAL, [S.l.], v. 1, n. 3, p. 107 - 110, apr. 2019. ISSN 2456-7825. Available at: <http://journal.srhu.edu.in/index.php/SRHUMJ/article/view/54>. Date accessed: 24 oct. 2019.
Section
Original Research